2-Methoxybenzoic acid → HCID 19612265, compound
Reaction equation
[OH:1][C:2]1[CH:17]=[C:16]([O:18][CH3:19])[CH:15]=[CH:14][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH3:13])=[O:5].[CH3:20][O:21]C1C=C(OC)C=CC=1C(C1C=CC=CC=1O)=O.COC1C=CC=CC=1C(O)=O.COC1C=C(OC)C=C(OC)C=1.COC1C(OC)=C(OC)C=CC=1C(C1C=CC=CC=1O)=O>>[CH3:20][O:21][C:17]1[C:2]([OH:1])=[C:3]([CH:14]=[CH:15][C:16]=1[O:18][CH3:19])[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH3:13])=[O:5]Participants
6
Procedure
According to the method of producing 2-hydroxy-4-methoxy-2'-methoxy benzophenone (4a) and 2,4-dimethoxy-2'-hydroxybenzophenone (4b), 2.00g (13.14 mmol) of 2-methoxybenzoic acid was reacted with 2.19g (13.04 mmol) of 1,3,5-trimethoxybenzene to give 2.20g (7.75 mmol) of 3,4-dimethoxy-2-hydroxy-2'-methoxybenzophenone (17a) and 2,3,4-trimethoxy-2'-hydroxy-benzophenone (17b). Then, based on example 3, 1.35 g (5.92 mmol) of 3,4-dihydroxy benzophenone (18H) as pale yellow powder was produced. The physical properties were measured and are listed below.
Sources & evidence
- ORD record
- ord-049ee825296a4526a4c8f1ea5ae383cf
- Source dataset
- uspto-grants-1996_02
- Patent number
- US05495005
Reaction notes
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