HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → 1-(2-(1,2,3,4-Tetrahydro-1-acetylquinolin-4-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | 1-(2-(1,2,3,4-Tetrahydroquinolin-4-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine | HCID 9842863 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-(2-(1,2,3,4-Tetrahydro-1-acetylquinolin-4-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine | HCID 18986572 | — |
Reaction Steps
A solution of 2.5 g of 1-(2-(1,2,3,4-tetrahydroquinolin-4-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine (dihydrochloride, m.p 235°-236°) in 35 ml of THF is treated with a solution of 0.9 g of a acetyl chloride in ml of THF, stirred for 2 hours at-50°, evaporated and worked up in the customary manner. 1-(2-(1,2,3,4-Tetrahydro-1-acetylquinolin-4-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05495022 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-9641ef6f480e4efb96b5b74a51128504 |
| Source note | uspto-grants-1996_02 |