Potassium Carbonate → 1-(2-(2,3,4,5-Tetrahydro-7-cyano-1-benzoxepin-5-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine

Participants

Reaction Steps

3.6 g of 2-(2,3,4,5-tetrahydro-7-cyano-1-benzoxepin-5-yl)ethyl bromide [obtainable starting from 2,3,4,5-tetrahydro-7-cyano-1-benzoexpin-5-one [sic] by reaction with triphenylethylphosphinium bromide, subsequent bromination of the product in the allyl position and reduction of the isolated double bond with diisobutyl-aluminiumhydride (DIBAH)], 1 equivalent of 4-(3,4-dimethoxyphenyl)piperidine hydrochloride, 3.8 g of K2CO3 and 2.1 g of KI are dissolved in 120 ml of ethyl methyl ketone and the mixture is boiled for 3 hours. Customary working up gives 1-(2-(2,3,4,5-tetrahydro-7-cyano-1-benzoxepin-5-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine.

Provenance & Evidence