2-(6-Nitrotetralin-1-yl)ethyl bromide → 1-(2-(6-Nitrotetralin-1-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine

HRID 2396882Notes

Reaction equation

HRID 2396882 reaction equation
Cl.[CH3:2][O:3][C:4]1[CH:5]=[C:6]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:7]=[CH:8][C:9]=1[O:10][CH3:11].[N+:18]([C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[CH:27]([CH2:31][CH2:32]Br)[CH2:26][CH2:25][CH2:24]2)([O-:20])=[O:19]>>[N+:18]([C:21]1[CH:22]=[C:23]2[C:28](=[CH:29][CH:30]=1)[CH:27]([CH2:31][CH2:32][N:15]1[CH2:14][CH2:13][CH:12]([C:6]3[CH:7]=[CH:8][C:9]([O:10][CH3:11])=[C:4]([O:3][CH3:2])[CH:5]=3)[CH2:17][CH2:16]1)[CH2:26][CH2:25][CH2:24]2)([O-:20])=[O:19]

Participants

3

Reactant 2

HCID 189865312-(6-Nitrotetralin-1-yl)ethyl bromideHCID 189865774-(3,4-Dimethoxyphenyl)piperidine hydrochloride

Product 1

HCID 189865861-(2-(6-Nitrotetralin-1-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine

Procedure

Analogously to Example 5, reaction of 4-(3,4-dimethoxyphenyl)piperidine hydrochloride with 2-(6-nitrotetralin-1-yl)ethyl bromide gives 1-(2-(6-nitrotetralin-1-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine.

Sources & evidence

ORD record
ord-dc89d4dec14740c58852d3ba57161688
Source dataset
uspto-grants-1996_02
Patent number
US05495022

Reaction notes

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