反应详情

Analogously to Example 2, reduction of 1-(1,2,3,4-tetrahydroquinolin-4-yl-acetyl)-4-(3,4-dimethoxyphenyl)piperidine [obtainable by reaction of 1,2,3,4-tetrahydroquinolin-4-one with diethylethoxycarbonyl methanephosphonate, subsequent hydrogenation with H2 /Pd-C, hydrolysis of the ester present and subsequent amide formation with 4-(3,4-dimethoxyphenyl)piperidine] using lithium aluminium hydride gives 1-(2-(1,2,3,4-tetrahydroquinolin-4-yl)ethyl)-4-(3,4-dimethoxyphenyl)piperidine, m.p. 235°-236° (dihydrochloride).