Potassium Nitrate → HCID 14834673, compound

HRID 2396939Notes

Reaction equation

HRID 2396939 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[C:4]([F:9])[C:3]=1[CH3:10].[N+:11]([O-])([O-:13])=[O:12].[K+]>S(=O)(=O)(O)O>[F:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([N+:11]([O-:13])=[O:12])=[C:4]([F:9])[C:3]=1[CH3:10]

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 146512521,2,4-Trifluoro-3-methylbenzene

Product 1

HCID 14834673HCID 14834673, compoundYield 94.9%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent2×

Conditions

Temperature
0 °C

Procedure

To 2,3,6-trifluorotoluene (55 g) is added conc. sulfuric acid (366 ml) and the mixture is cooled to 0° C. Thereto a solution of potassium nitrate (44 g) in conc. sulfuric acid (120 ml) is added dropwise at below 10° C. and then the mixture is stirred for 15 minutes. The mixture is poured into ice-water, extracted with diethyl ether, and the extract is washed with water and dried. The solvent is distilled off to give 2,3,6-trifluoro-5-nitrotoluene (68.25 g), as yellow oil.

Workup

  1. extractionextracted with diethyl ether
  2. washthe extract is washed with water
  3. customdried
  4. distillationThe solvent is distilled off

Sources & evidence

ORD record
ord-c6fd7d225e8249b3af851ebe53034a37
Source dataset
uspto-grants-1996_02
Patent number
US05495020

Reaction notes

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