Acetic Anhydride → HCID 23359034, compound

HRID 2396955Notes

Reaction equation

HRID 2396955 reaction equation
[F:1][C:2]1[C:8]([CH3:9])=[C:7]([F:10])[C:6]([F:11])=[CH:5][C:3]=1[NH2:4].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[F:1][C:2]1[C:8]([CH3:9])=[C:7]([F:10])[C:6]([F:11])=[CH:5][C:3]=1[NH:4][C:12](=[O:14])[CH3:13]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 146512532,4,5-Trifluoro-3-methylaniline

Product 1

HCID 23359034HCID 23359034, compound

Procedure

To 2,4,5-trifluoro-3-methylaniline (1 g) is added acetic anhydride (3 ml) at room temperature with stirring and the mixture is stirred for 15 minutes. The reaction mixture is poured into ice-water, extracted with dichloromethane, and the extract is washed with water and dried. The solvent is distilled off to give 2,4,5-trifluoro-3-methyl-N-acetylaniline (1.14 g), as white crystals.

Workup

  1. stirringthe mixture is stirred for 15 minutes
  2. extractionextracted with dichloromethane
  3. washthe extract is washed with water
  4. customdried
  5. distillationThe solvent is distilled off

Sources & evidence

ORD record
ord-c2cebb32e5a141fab7892d3f84c4c075
Source dataset
uspto-grants-1996_02
Patent number
US05495020

Reaction notes

Loading…