HCID 15075817, compound → HCID 54044557, compound

HRID 2396965Notes

Reaction equation

[Cl:1][C:2]1[C:3]([F:19])=[C:4]([C:13]([CH3:18])=[C:14]([F:17])[C:15]=1[F:16])[C:5]([CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6].[CH:20]([O-])([O-])[O:21][CH2:22][CH3:23]>>[Cl:1][C:2]1[C:3]([F:19])=[C:4]([C:13]([CH3:18])=[C:14]([F:17])[C:15]=1[F:16])[C:5]([C:7](=[CH:20][O:21][CH2:22][CH3:23])[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6]

Participants

Reactant 2

HCID 15075817HCID 15075817, compound

HCID 53630039Ethylorthoformate

Product 1

HCID 54044557HCID 54044557, compoundYield 100.8%

Procedure

Employing ethyl 3-chloro-2,4,5-trifluoro-6-methylbenzoylacetate (300 mg) and ethyl orthoformate (550 mg), the procedure of Reference Example 20 is repeated to give ethyl 2-(3-chloro-2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate (360 mg), as brown oil.

Sources & evidence

ORD record: ord-6437c70554cd445f874021e4af52311e
Source dataset: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05495020

Reaction notes

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