Cyclopropylamine → HCID 178471857, compound

HRID 2396966Notes

Reaction equation

[Cl:1][C:2]1[C:3]([F:23])=[C:4]([C:17]([CH3:22])=[C:18]([F:21])[C:19]=1[F:20])[C:5]([C:7](=[CH:13]OCC)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6].[CH:24]1([NH2:27])[CH2:26][CH2:25]1>>[Cl:1][C:2]1[C:3]([F:23])=[C:4]([C:17]([CH3:22])=[C:18]([F:21])[C:19]=1[F:20])[C:5]([C:7](=[CH:13][NH:27][CH:24]1[CH2:26][CH2:25]1)[C:8]([O:10][CH2:11][CH3:12])=[O:9])=[O:6]

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 54044557HCID 54044557, compound

Product 1

HCID 178471857HCID 178471857, compoundYield 110.4%

Procedure

Employing ethyl 2-(3-chloro-2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate (360 mg) and cyclopropylamine (60 mg), the procedure of Reference Example 21 is repeated to give ethyl 2-(3-chloro-2,4,5-trifluoro-6-methylbenzoyl)-3-cyclopropylaminoacrylate (410 mg), as brown oil.

Sources & evidence

ORD record: ord-2e4dbdf0577e44c5923e4bcbaa933956
Source dataset: uspto-grants-1996_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05495020

Reaction notes

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