HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Cyclopropyl-6,7,8-trifluoro-5-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | HCID 23359004 | HCID 23359004 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1-Cyclopropyl-6,7,8-trifluoro-5-ethyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 14651263 | 91.6% |
Reaction Steps
Employing ethyl 1-cyclopropyl-6,7,8-trifluoro-5-ethyl-1,4-dihydro-4 -oxoquinoline-3-carboxylate (5 g), conc. hydrochloric acid (11 ml), water (4.4 ml) and acetic acid (44 ml), the procedure of Reference Example 23 is repeated to give 1-cyclopropyl-6,7,8-trifluoro-5-ethyl-1,4-dihydro-4 -oxoquinoline-3-carboxylic acid (4.2 g), as white powder, m.p. 197°-198° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05495020 |
| Source dataset | uspto-grants-1996_02 |
| ORD ID | ord-6d6f8a8251494cf9ab0fe4425ec02dc3 |
| Source note | uspto-grants-1996_02 |