(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol → HCID 15337568, compound

HRID 2396996Notes

Reaction equation

HRID 2396996 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[NH:15]1[CH:19]=[CH:18][N:17]=[N:16]1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@H:12]([N:16]2[N:17]=[CH:18][CH:19]=[N:15]2)[CH3:13])[CH2:11][O:10]1

Participants

3

Reactant 2

HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanolHCID 178418936HCID 178418936, compound

Product 1

HCID 15337568HCID 15337568, compound

Procedure

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (202 mg) and 1H-1,2,3-triazole (0.17 ml), (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-(2H-1,2,3-triazol-2-yl)ethyl]oxirane (172 mg) was obtained by the same way as in Reference Example 10.

Sources & evidence

ORD record
ord-fb768fc1392d4d38a5745e4b0fc65c12
Source dataset
uspto-grants-1996_02
Patent number
US05495024

Reaction notes

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