1H-Purine, 6-methyl- → HCID 57109516, compound

HRID 2397004Notes

Reaction equation

HRID 2397004 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[CH3:15][C:16]1[N:24]=[CH:23][N:22]=[C:21]2[C:17]=1[NH:18][CH:19]=[N:20]2>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@H:12]([N:20]2[CH:19]=[N:18][C:17]3[C:21]2=[N:22][CH:23]=[N:24][C:16]=3[CH3:15])[CH3:13])[CH2:11][O:10]1

Participants

3

Reactant 2

HCID 52875471H-Purine, 6-methyl-HCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol

Product 1

HCID 57109516HCID 57109516, compoundYield 46%

Procedure

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (587 mg) and 6-methylpurine (353 mg), (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methyl-9(9H)-purinyl]ethyl]oxirane (383 mg) was obtained as a white powder by the same way as in Reference Example 2.

Sources & evidence

ORD record
ord-f0c1b9ce3f9d4b2a8f6d2665ebd43b09
Source dataset
uspto-grants-1996_02
Patent number
US05495024

Reaction notes

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