2,6-Dichloropurine → HCID 57168504, compound

HRID 2397006Notes

Reaction equation

HRID 2397006 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C@:9]1([C@@H:12](O)[CH3:13])[CH2:11][O:10]1.[Cl:15][C:16]1[N:24]=[C:23]2[C:19]([NH:20][CH:21]=[N:22]2)=[C:18]([Cl:25])[N:17]=1>>[Cl:15][C:16]1[N:24]=[C:23]2[C:19]([N:20]=[CH:21][N:22]2[C@@H:12]([C@@:9]2([C:3]3[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=3[F:1])[CH2:11][O:10]2)[CH3:13])=[C:18]([Cl:25])[N:17]=1

Participants

3

Reactant 2

HCID 53244122,6-DichloropurineHCID 10631861(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol

Product 1

HCID 57168504HCID 57168504, compoundYield 17.5%

Procedure

Using (1S)-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl]ethanol (578 mg) and 2,6-dichloropurine (490 mg), (2S)-2-[(1R)-1-[2,6-dichloro-9(9H)-purinyl]ethyl]-2-(2,4-difluorophenyl)oxirane (168 mg) was obtained by the same way as in Reference Example 2.

Sources & evidence

ORD record
ord-2fedf27fa01b4be496ce735bde25e096
Source dataset
uspto-grants-1996_02
Patent number
US05495024

Reaction notes

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