1H-1,2,4-Triazole → HCID 53678942, compound

HRID 2397016Notes

Reaction equation

HRID 2397016 reaction equation
[NH:1]1[CH:5]=[N:4][CH:3]=[N:2]1.Cl[C:7]1[N:15]=[C:14]2[C:10]([N:11]=[CH:12][N:13]2[C@@H:16]([C@@:18]2([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=3[F:28])[CH2:20][O:19]2)[CH3:17])=[C:9](Cl)[N:8]=1>>[N:1]1([C:7]2[N:15]=[C:14]3[C:10]([N:11]=[CH:12][N:13]3[C@H:16]([CH3:17])[C@:18]([C:21]3[CH:26]=[CH:25][C:24]([F:27])=[CH:23][C:22]=3[F:28])([OH:19])[CH2:20][N:1]3[CH:5]=[N:4][CH:3]=[N:2]3)=[C:9]([N:1]3[CH:5]=[N:4][CH:3]=[N:2]3)[N:8]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

3

Reactant 2

HCID 92571H-1,2,4-TriazoleHCID 57168504HCID 57168504, compound

Product 1

HCID 53678942HCID 53678942, compoundYield 14.6%

Procedure

Using 1H-1,2,4-triazole (59 mg) and (2S)-2-[(1R)-1-[2,6-dichloro-9 (9H)-purinyl]ethyl]-2-(2,4-difluorophenyl) oxirane (168 mg), Compound 50 (21 mg) was obtained as a white powder by the same way as in Example 1.

Sources & evidence

ORD record
ord-4eb9c6d48fa84930adc71e83c9540721
Source dataset
uspto-grants-1996_02
Patent number
US05495024

Reaction notes

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