Dimethylcyanamide → HCID 19043698, compound

HRID 2397044Notes

Reaction equation

HRID 2397044 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=3)=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[Br:24]N1C(=O)CCC1=O.C(#N)N(C)C>C(Cl)(Cl)(Cl)Cl>[Br:24][CH2:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([Cl:23])[CH:17]=3)=[O:15])=[CH:12][CH:13]=2)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 15112DimethylcyanamideHCID 67184N-bromobutanimideHCID 19043690HCID 19043690, compound

Product 1

HCID 19043698HCID 19043698, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A mixture of 5.0 g of 3,4-dichlorophenyl 4'-methyl-4-biphenylyl ketone, 2.7 g of N-bromosuccinimide and 20 mg of azaisobutyronitrile in 70 ml of carbon tetrachloride is heated to boiling under reflux. The precipitated material is filtered and the filtrate is evaporated. The residue is recrystallized from toluene/cyclohexane. 3,4-Dichlorophenyl 4'-bromomethyl-4-biphenylyl ketone is obtained.

Workup

  1. temperatureis heated
  2. temperatureunder reflux
  3. filtrationThe precipitated material is filtered
  4. customthe filtrate is evaporated
  5. customThe residue is recrystallized from toluene/cyclohexane

Sources & evidence

ORD record
ord-da5abe27d21b4b32b077f84d459de307
Source dataset
uspto-grants-1996_02
Patent number
US05495048

Reaction notes

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