Ammonia → HCID 18986932, compound

Participants

Reaction Steps

1.84 g of aluminum lithium hydride was added to a solution of 10.76 g of the crude ethyl 3-[5-chloro-2-(2-phenylethoxy)phenyl]propionate in 100 ml of tetrahydrofuran under ice-cooling and the mixture was stirred at the same temperature for 1 hour. Then 25% aqueous ammonia was added thereto until no hydrogen gas evolved any more. After filtering with the use of Celite and anhydrous magnesium sulfate, the solvent was evaporated under reduced pressure. The residue thus obtained was subjected to silica gel column chromatography (developing solvent; ethyl acetate:n-hexane =1:9) to give 3.31 g of 3-[5-chloro-2-(2-phenylethoxy)phenyl]propanol.

Provenance & Evidence