Oxalic Acid → HCID 18986853, compound

HRID 2397060Notes

Reaction equation

HRID 2397060 reaction equation
[CH2:1]([N:4]([CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=1[O:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3].[C:27]([OH:32])(=[O:31])[C:28]([OH:30])=[O:29]>C(O)C>[C:27]([OH:32])(=[O:31])[C:28]([OH:30])=[O:29].[CH2:1]([N:4]([CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[C:15]([Cl:17])[CH:14]=[CH:13][C:12]=1[O:18][CH2:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[CH2:5][CH2:6][CH3:7])[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 971Oxalic AcidHCID 10738132HCID 10738132, compound

Product 1

HCID 18986853HCID 18986853, compoundYield 61.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 0.50 g of N,N-di-n-propyl-3-[5-chloro-2-(2-phenylethoxy)phenyl]propylamine in 10 ml of ethanol, was added a solution of 120 mg of oxalic acid in 5 ml of ethanol. After evaporation of the solvent, the obtained crystals were recrystallized from ethyl acetate to give 380 mg of N,N-di-n-propyl-3-[5-chloro-2-(2-phenylethoxy)phenyl]propylamine oxalate.

Workup

  1. customAfter evaporation of the solvent
  2. customthe obtained crystals were recrystallized from ethyl acetate

Sources & evidence

ORD record
ord-f95dabded2a44a1784b096c0440c0537
Source dataset
uspto-grants-1996_02
Patent number
US05495046

Reaction notes

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