Trifluoroacetic acid → HCID 18986934, compound

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Reaction Steps

3,5-Dimethylbenzyl N-t-butoxycarbonyl-2-(9-fluorenyl)glycinate (Example 9d, 0.5g) was dissolved in trifluoroacetic acid (10ml) for 40 minutes then evaporated in vacuo. To a solution of the residue in pyridine (10ml) was added acetic anhydride (1ml) for 16h. The solvent was removed in vacuo and the residue crystallised from diethyl ether/petroleum ether bp 60°-80° C. to give the title compound mp 162°-164° C. Found: C, 78.19; H,. 6.26; N, 3.45. C26H25NO3 requires C,. 78.17; H, 6.30; N, 3.50%. m/z (CI+)=400 (M+H), (CI-)=398 (M-H).

Provenance & Evidence