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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2397138Generated: October 30, 2026

Benzenesulfonyl fluoride, p-chloro- → 1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-

https://huagongshe.com/reaction/2397138

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzenesulfonyl fluoride, p-chloro-HCID 94992—
ReactantN-Boc-cis-4-hydroxy-L-proline methyl esterHCID 10752873—
Reagent1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
SolventTetrahydrofuranHCID 8028—
Product1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-HCID 1097777325%

Provenance & Evidence

DOI10.1021/jacs.8b01523
Source datasetDeoxyfluorination screen
ORD IDord-4389dac19b99452180cd2c0b5baac96b
Source noteDeoxyfluorination screen