HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2397152Generated: October 29, 2026
4-Nitrobenzenesulfonyl fluoride → 1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-
https://huagongshe.com/reaction/2397152
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-Nitrobenzenesulfonyl fluoride | HCID 188246 | — |
| Reactant | N-Boc-cis-4-hydroxy-L-proline methyl ester | HCID 10752873 | — |
| Reagent | 2-tert-Butyl-1,1,3,3-tetramethylguanidine | HCID 3571581 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel- | HCID 10977773 | 40% |
Provenance & Evidence
| DOI | 10.1021/jacs.8b01523 |
|---|
| Source dataset | Deoxyfluorination screen |
|---|
| ORD ID | ord-126044af69774ff9904328f3b780c561 |
|---|
| Source note | Deoxyfluorination screen |
|---|
