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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2397155Generated: October 30, 2026

Perfluoro-1-butanesulfonyl fluoride → 1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-

https://huagongshe.com/reaction/2397155

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPerfluoro-1-butanesulfonyl fluorideHCID 67814—
ReactantN-Boc-cis-4-hydroxy-L-proline methyl esterHCID 10752873—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
SolventTetrahydrofuranHCID 8028—
Product1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4R)-rel-HCID 1097777374%

Provenance & Evidence

DOI10.1021/jacs.8b01523
Source datasetDeoxyfluorination screen
ORD IDord-8970dc6e6fc947adb89f4dd248d06b24
Source noteDeoxyfluorination screen