Pyridine → HCID 20324728, compound

HRID 2397184Notes

Reaction equation

HRID 2397184 reaction equation
[N:1]1C=CC=CC=1.Br.[Br:8][CH2:9][CH2:10]N.[Cl:12][CH2:13][S:14](Cl)(=[O:16])=[O:15]>C(Cl)(Cl)Cl>[Br:8][CH2:9][CH2:10][CH:13]([Cl:12])[S:14]([NH2:1])(=[O:16])=[O:15]

Participants

5

Reactant 3

HCID 1049PyridineHCID 77054(Chloromethyl)sulfonyl chlorideHCID 27742172-Bromoethylamine hydrobromide

Product 1

HCID 20324728HCID 20324728, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Pyridine (17.8 ml.) was added over a period of 30 minutes to a cooled solution (15- 20° C.) of 2-bromoethylamine hydrobromide (20.5 g., 0.10 mole) and chloromethanesulfonyl chloride (14.9 g., 0.10 mole) in chloroform. The mixture was stirred for 1 hour and then washed with water (100 ml.) and dilute hydrochloric acid (50 ml.). The solution was dried over magnesium sulfate. The solvent was evaporated in vacuo. There was obtained 10 g. of a dark oil, the title compound. Structure was confirmed by infrared analysis.

Workup

  1. washwashed with water (100 ml.) and dilute hydrochloric acid (50 ml.)
  2. dry with materialThe solution was dried over magnesium sulfate
  3. customThe solvent was evaporated in vacuo
  4. customThere was obtained 10 g

Sources & evidence

ORD record
ord-445c00fbb2e34c98973a0aa60d45d51b
Source dataset
uspto-grants-1977_05
Patent number
US04021229

Reaction notes

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