HCID 86734706, compound → HCID 21437150, compound

Participants

Reaction Conditions

Reaction Steps

15 Grams of 1-(2,4,6-trichlorophenyl)-3-[3-{α-(2,4-di-tert-amylphenoxy)butyramido}benzamido]-4-(1-pyridinio)-5-oxo-2-pyrazoline bromide (Compound 1-2; m.p: 260° - 262° C.) was dissolved in 300 ml of acetic acid, with 10 g of Raney nickel being added thereto. The resulting mixture was maintained at 80° C. and vigorously stirred for 24 hours in a stream of hydrogen. Then, the reaction product was treated in the same manner as described in Example 1. Upon recrystallizing from a chloroform-ethyl acetateacetonitrile mixed solvent (1:1:10 by volume), 8.5 g of Compound 2-2 having a melting point of 186° - 190° C. was obtained.

Provenance & Evidence