HCID 178418361, compound → HCID 21437152, compound

Participants

Reaction Steps

7.9 grams of 1-(2,4,6-trichlorophenyl)-3-[3-{(2,4 -di-tert-amylphenoxy)acetamido}benzamido]-4-(3-ethyl-4-methyl-1-pyridinio)-5-oxo-2-pyrazolin-4-ide (Compound 1-3; m.p.; 162° - 165° C.) was dissolved in 500 ml of ethanol, and about 10 g of Raney nickel catalyst was added thereto. Then, reaction was conducted in an autoclave at 80° C. for 20 hours with an initial hydrogen pressure of 60 atmospheres. After the reaction, the catalyst was removed, followed by distilling off the solvent. Upon crystallizing the resulting residue from acetonitrile-ethyl acetate (10:1 by volume) 4.2 g of Compound 2-3 having a melting point of 145° - 155° C. was obtained.

Provenance & Evidence