2-ACETAMIDO-6-METHYLPYRIDINE → N-Ethyl-6-methylpyridin-2-amine

HRID 2397210Notes

Reaction equation

HRID 2397210 reaction equation
[C:1]([NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][CH:6]=1)(=O)[CH3:2].B#B>>[CH2:1]([NH:4][C:5]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][CH:6]=1)[CH3:2]

Participants

3

Reactant 2

HCID 2204862-ACETAMIDO-6-METHYLPYRIDINEHCID 6328200Diboron

Product 1

HCID 3016051N-Ethyl-6-methylpyridin-2-amine

Procedure

The process for producing 6-ethylamino-2-picoline which comprises reacting 6-acetamido-2-picoline with diborane in an inert non-polar solvent at about 0° to 70° C. to produce 6-ethylamino-2-picoline and using a low boiling petroleum solvent to separate the soluble 6-ethylamino-2-picoline from the insoluble 6-acetamido-2-picoline.

Workup

  1. customat about 0° to 70° C.

Sources & evidence

ORD record
ord-a208b0a2be3d488c8947b8bd97574c7f
Source dataset
uspto-grants-1977_05
Patent number
US04021437

Reaction notes

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