反应详情

温度

50 °C

A solution of 4.52 g. (0.04 m) of ethyl isocyanoacetate and 3.60 g. (0.04 m) of ethyl thioformate in 15 ml. of absolute ethanol is added dropwise with vigorous stirring to a suspension of 0.25 g. of sodium cyanide in 10 ml. ethanol at 15° C. An exotherm developes during the addition and is moderated with ice-bath cooling. The reaction mixture is warmed at 50° C. for 30 minutes. The solvent is then removed in vacuo and the resulting residue extracted with several portions of hot hexane to give a 92% yield of 4-ethoxycarbonyl thiazole.

1. customat 15° C
2. additionAn exotherm developes during the addition
3. customis moderated with ice-bath
4. temperaturecooling
5. customThe solvent is then removed in vacuo
6. extractionthe resulting residue extracted with several portions of hot hexane