Benzene → HCID 21437196, compound

HRID 2397224Notes

Reaction equation

HRID 2397224 reaction equation
[CH3:1][C:2]1[NH:3][C:4]([CH2:27][CH2:28][CH3:29])=[C:5]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:7]=1[C:8]([O:10][CH2:11][CH3:12])=[O:9].Cl[CH2:31][O:32][CH2:33][CH3:34].C1C=CC=CC=1>CCCCCC>[CH2:33]([O:32][CH2:31][N:3]1[C:4]([CH2:27][CH2:28][CH3:29])=[C:5]([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH:6]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([N+:19]([O-:21])=[O:20])[CH:14]=2)[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:2]1[CH3:1])[CH3:34]

Participants

5

Reactant 3

HCID 241BenzeneHCID 18523Chloromethyl ethyl etherHCID 12786008HCID 12786008, compound

Product 1

HCID 21437196HCID 21437196, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

By following the same procedure as in Example 25 except that 0.5 g. of diethyl 2-methyl-6-propyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate and 0.5 g. of chloromethoxyethane were used as the starting materials, benzene was used as the eluant, and hexane was used as the solvent for recrystallization, 0.35 g. of colorless acicular crystals of diethyl 1-ethoxymethyl-2-methyl-4-(3-nitrophenyl)-6-propyl-1,4-dihydropyridine-3,5-dicarboxylate melting at 97° C. were obtained.

Workup

  1. customwas used as the solvent for recrystallization, 0.35 g

Sources & evidence

ORD record
ord-23a5a07a793444e28d8364f0a954ffae
Source dataset
uspto-grants-1977_05
Patent number
US04021434

Reaction notes

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