反应详情

To a solution of 3,4,5-trimethoxybenzylamine (2.2 mL, 12.7 mmol) in 2-butanone (20 mL) was added 1,3-propane sultone (1.66 g, 13.3 mmol). The mixture was stirred at reflux for 2 hours. The reaction mixture was cooled to room temperature. The solid was collected by filtration, washed with acetone (2×25 mL) and dried in vacuo. The product was suspended in 90% Acetone/MeOH (75 mL). The suspension was stirred at reflux for 30 sec., the solid was collected by filtration, and dried in vacuo; affording compound AY, 2.61 g (64%).

1. temperatureat reflux for 2 hours
2. filtrationThe solid was collected by filtration
3. washwashed with acetone (2×25 mL)
4. customdried in vacuo
5. stirringThe suspension was stirred
6. temperatureat reflux for 30 sec
7. filtration, the solid was collected by filtration
8. customdried in vacuo