HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 8-chloro-1-[[(cyclopropylmethyl)amino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | N-Methylcyclopropanamine | HCID 11029756 | — |
| Reactant | 8-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine | HCID 12612348 | — |
| Product | 8-chloro-1-[[(cyclopropylmethyl)amino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 21437247 | — |
Reaction Steps
In the manner given in Example 2, potassium iodide, 8-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine in tetrahydrofuran is treated with methylcyclopropylamine to give 8-chloro-1-[(cyclopropylmethylamino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04021441 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-5a15870363814970bed2b02bc8e612b9 |
| Source note | uspto-grants-1977_05 |