HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → 8-chloro-1-[[(cyclopropylmethyl)methylamino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | 8-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo-[4,3-a][1,4]benzodiazepine | HCID 12612348 | — |
| Reactant | (Cyclopropylmethyl)methylamine | HCID 12919209 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 8-chloro-1-[[(cyclopropylmethyl)methylamino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine | HCID 21437268 | — |
Reaction Steps
In the manner given in Example 2, potassium iodide and 8-chloro-1-(chloromethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine in tetrahydrofuran are treated with methyl(cyclopropylmethyl)amine to give 8-chloro-1-[[(cyclopropylmethyl)methylamino]methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04021441 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-c8c207ffb6394ae594eeaabb8e6788b0 |
| Source note | uspto-grants-1977_05 |