Water → Hexamethyldisiloxane

Participants

Reaction Steps

N-Methylglucamine (10 g, 0.05 mol) was suspended (partly dissolved) in dry freshly-distilled pyridine and cooled in an ice-bath. Trimethyl silylchloride (30 g, 0.28 mol) was added in portions so that the temperature did not rise above 20°- 25°. After 1 hour the reaction slurry was poured into ether (200 ml) and water (200 ml) and shaken; the ether layer was washed several times with water, dried and evaporated at 50°-60° to leave the oily per-trimethylsilyl ether containing a trace of pyridine. Yield: ca. 20 g (50%).

Provenance & Evidence