Cyclohexylamine → HCID 21437932, compound

HRID 2397369Notes

Reaction equation

HRID 2397369 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](=O)[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1.C1CCCCC1.C1(N)CCCCC1>C(OCC)(=O)C.CO>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 7965CyclohexylamineHCID 8078CyclohexaneHCID 217676(1,1'-Biphenyl)-4-butanoic acid, 2',4'-difluoro-gamma-oxo-

Product 1

HCID 21437932HCID 21437932, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

Prepared analogous to Example 1 from 4-(2',4'-difluoro-4-biphenylyl)-4-oxo-butyric acid. Yield: 39% of theory; m.p. 76°-77° C. (from cyclohexane). Melting point of the cyclohexylamine salt: 127°-128° C. (from ethyl acetate/methanol 9:1).

Sources & evidence

ORD record
ord-30211acef50e4d389ff8055936566752
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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