Perchloric Acid → HCID 21437941, compound

Participants

Reaction Steps

18.6 gm of 4-(2'-chloro-4-biphenylyl)-4-hydroxybutyric acid (obtained by acidifying 20 gm of its sodium salt and extraction with ethyl acetate) were hydrogenated in 200 ml of glacial acetic acid in the presence of 2 ml of perchloric acid and in the presence of palladium/barium sulfate (5%) at room temperature and at a hydrogen pressure of 5 atmospheres. After filtration, the solvent was evaporated and the residue admixed with water; the crystalline acid was collected and dried. Yield: 70% of theory; m.p. 60°-61° C. (from petroleum ether). Melting point of the cyclohexylamine salt: 143°-144° C. (from water).

Provenance & Evidence