Hydrochloric Acid → HCID 21437928, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 6.6 gm (0.018 mol) of ethyl 4-(2'-bromo-4-biphenylyl)-4-oxo-butyrate (m.p. 61°-62° C.), 3 gm of 100% hydrazine hydrate and 100 ml of diethyleneglycol was heated at 100° C. for 20 minutes. Then, 5 gm of pulverized potassium hydroxide were added. After refluxing for 5 hours, the reaction mixture was poured into 500 ml of water, acidified with dilute hydrochloric acid, and the precipitate was dissolved in ether. The ether solution was washed with water, dried and evaporated; the residue was dissolved in acetone, and by addition of cyclohexylamine the cyclohexylamine salt of 4-(2'-bromo-4-biphenylyl)-butyric acid, m.p. 148°-149° C. (from acetone), was obtained. Melting point of the free acid: 63° C. (from cyclohexane).

Provenance & Evidence