Cyclohexylamine → HCID 21437939, compound

HRID 2397395Notes

Reaction equation

HRID 2397395 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:21])[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1.C1CCCCC1.C(OCC)(=O)C.C1(N)CCCCC1>CC(C)=O.C(OCC)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([OH:21])[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 7965CyclohexylamineHCID 217676(1,1'-Biphenyl)-4-butanoic acid, 2',4'-difluoro-gamma-oxo-HCID 21867204Cyclohexane ethylacetate

Product 1

HCID 21437939HCID 21437939, compound

Reagents, catalysts & solvents 1

HCID 21584569Ethylacetate acetoneSolvent

Procedure

Prepared analogous to Example 25 from 4-(2',4'-difluoro-4-biphenylyl)-4-oxo-butyric acid. Melting point 111°-112.5° C. (from cyclohexane/ethyl acetate 4:1); melting point of the cyclohexylamine salt: 160°-161° C. (from acetone/ethyl acetate 1:2).

Sources & evidence

ORD record
ord-40d7ac0411704eccaa3897e1c9691f7f
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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