Cyclohexylamine → HCID 21437995, compound

HRID 2397396Notes

Reaction equation

HRID 2397396 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](=[O:21])[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1.C1(N)CCCCC1>C(OCC)(=O)C.CO>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([OH:21])[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 7965CyclohexylamineHCID 21437918HCID 21437918, compound

Product 1

HCID 21437995HCID 21437995, compound

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

Prepared analogous to Example 25 from 4-(2'-chloro4'-fluoro-4-biphenylyl)-4-oxo-butyric acid. Melting point 78°-79° C. (from benzene/petroleum ether 3:2); melting point of the cyclohexylamine salt: 161°-162° C. (from ethyl acetate/methanol 1:1).

Sources & evidence

ORD record
ord-6e6ee383f1e6477f9f3f0c7b416349e2
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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