Cyclohexylamine → 4-(4'-Fluoro-4-biphenylyl)-4-hydroxy-butyric acid

HRID 2397404Notes

Reaction equation

HRID 2397404 reaction equation
C1(N)CCCCC1.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21](=[O:28])[CH2:22][CH2:23][C:24]([O:26]C)=[O:25])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1>>[F:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:20]=[CH:19][C:18]([CH:21]([OH:28])[CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[CH:17][CH:16]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 15541120Methyl 4-(4'-fluoro-4-biphenylyl)-4-oxo-butyrate

Product 1

HCID 214379434-(4'-Fluoro-4-biphenylyl)-4-hydroxy-butyric acid

Procedure

Melting point of the cyclohexylamine salt: 174°-176° C. Prepared analogous to Example 40 from methyl 4-(4'-fluoro-4-biphenylyl)-4-oxo-butyrate.

Workup

  1. custom174°-176° C

Sources & evidence

ORD record
ord-0f15a732af3d4714ac47577a5c2a58f5
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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