HCID 21437916, compound → HCID 21437913, compound

Participants

Reaction Steps

6 gm (0.02 mol) of 4-(2'-nitro-4-biphenylyl)-4 -hydroxy-butyric acid (m.p. 114°-115° C.) were hydrogenated in 60 ml of methanol in the presence of 0.6 gm of platinum dioxide as a catalyst, at room temperature and atmospheric pressure. After absorption of the calculated quantity of hydrogen, the catalyst was vacuum-filtered off, and the solvent was distilled off. The residue, which solidified after some time, was recrystallized from methanol, yielding 4-(2' -amino-4-biphenylyl)-4-hydroxy-butyric acid, m.p. 102°-103° C. Melting point of the cyclohexylamine salt: 157°-158° C. (decomp,; precipitated from ethyl acetate and recrystallized from ethyl acetate/isopropanol).

Provenance & Evidence