Methanol → HCID 21437945, compound

HRID 2397413Notes

Reaction equation

HRID 2397413 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[O:19][C:17](=[O:18])[CH2:16][CH2:15]2)=[CH:10][CH:9]=1.C[OH:21].[OH-].[Na+]>O>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[CH:9]=[CH:10][C:11]([CH:14]([OH:19])[CH2:15][CH2:16][C:17]([OH:18])=[O:21])=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 21437910HCID 21437910, compound

Product 1

HCID 21437945HCID 21437945, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 5.44 gm (0.02 mol) of γ-(2'-chloro-4-biphenylyl)-γ-butyrolactone (b.p. 212°-213° C. at 0.03 mm Hg), 50 ml of methanol, 1 gm of sodium hydroxide and 2 ml of water was boiled for 2 hours. The reaction mixture was then evaporated, the residue was distributed between dilute hydrochloric acid and ethyl acetate, and the cyclohexylamine salt was precipitated from the washed and dried ethyl acetate solution. Yield: 5.8 gm m.p. of the cyclohexylamine salt: 158°-159° C. (from water).

Workup

  1. customThe reaction mixture was then evaporated
  2. customthe cyclohexylamine salt was precipitated from the
  3. washwashed
  4. custom158°-159° C. (from water)

Sources & evidence

ORD record
ord-ad089379a8c246169caaf51e7f1e5407
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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