HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclohexylamine → 4-(4'-Chloro-2'-methyl-4-biphenylyl)-4-hydroxy-butyric acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclohexylamine | HCID 7965 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | 4-(4'-Chloro-2'-methyl-4-biphenylyl)-4-oxo-butyric acid | HCID 21437970 | — |
| Solvent | Ethylene chloride ethyl acetate | HCID 20136152 | — |
| Product | 4-(4'-Chloro-2'-methyl-4-biphenylyl)-4-hydroxy-butyric acid | HCID 21437994 | 96% |
Reaction Steps
Prepared analogous to Example 25 by reduction of 4-(4'-chloro-2'-methyl-4-biphenylyl)-4-oxo-butyric acid (m.p. 153°-154° C.) with sodium borohydride. Yield: 96%. Melting point of the cyclohexylamine salt: 139°-140° C. (from ethylene chloride/ethyl acetate 5:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04021479 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-83a3eb6f20af4a248e1f8d6a61e185bb |
| Source note | uspto-grants-1977_05 |