Cyclohexylamine → 4-(4'-Amino-3'-bromo-4-biphenylyl)-4-hydroxy-butyric acid

HRID 2397415Notes

Reaction equation

HRID 2397415 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[CH:4][C:3]=1[Br:21].C1(N)CCCCC1>>[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([CH:14]([OH:20])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:13]=2)=[CH:4][C:3]=1[Br:21]

Participants

3

Reactant 2

HCID 7965CyclohexylamineHCID 214379204-(4'-Amino-3'-bromo-4-biphenylyl)-4-oxo-butyric acid

Product 1

HCID 214379914-(4'-Amino-3'-bromo-4-biphenylyl)-4-hydroxy-butyric acidYield 67%

Procedure

Prepared analogous to Example 25 by reduction of 4-(4'-amino-3'-bromo-4-biphenyly)-4-oxo-butyric acid. Yield: 67%; m.p. 112°-113° C. (decomp.). Melting point of the cyclohexylamine salt: 183° C.

Workup

  1. custom183° C.

Sources & evidence

ORD record
ord-16e47872cdc34175bbaa04d7d09c923b
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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