Isobutylamine → HCID 21437987, compound

HRID 2397419Notes

Reaction equation

HRID 2397419 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([C:17](=[O:23])[CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:13][CH:12]=1)(=[O:3])[CH3:2].C1(N)CCCCC1.C(N)C(C)C>>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1[CH:16]=[CH:15][C:14]([CH:17]([OH:23])[CH2:18][CH2:19][C:20]([OH:22])=[O:21])=[CH:13][CH:12]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 3

HCID 6558IsobutylamineHCID 7965CyclohexylamineHCID 214379404-(2'-Acetamido-4-biphenylyl)-4-oxo-butyric acid

Product 1

HCID 21437987HCID 21437987, compoundYield 60%

Procedure

Prepared analogous to Example 25 from 4-(2'-acetamido-4-biphenylyl)-4-oxo-butyric acid (m.p. 209°-210° C.). Melting point of the cyclohexylamine salt: 143° C.; melting point of the isobutylamine salt: 125°-126° C.; yield: 60% of theory.

Workup

  1. custom143° C.
  2. custom125°-126° C.

Sources & evidence

ORD record
ord-874fb8859a074cf1a77ffddc9718af86
Source dataset
uspto-grants-1977_05
Patent number
US04021479

Reaction notes

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