反应详情

To a solution of 15 gm (0.05 mol) of ethyl 4-(2'-fluoro-4-biphenylyl)-4-oxo-butyrate in 100 ml of methanol 1.9 gm (0.05 mol) of sodium borohydride were added at a temperature between 0° and 5° C., while stirring. The precipitate was vacuum-filtered off and dissolved in ether. The ethereal solution was washed with an aqueous sodium bicarbonate solution and then with water, dried and evaporated. The residual oil was recrystallized from cyclohexane. Yield: 12 gm (79.5% of theory), m.p. 61°-62° C.

1. filtrationThe precipitate was vacuum-filtered off
2. dissolutiondissolved in ether
3. washThe ethereal solution was washed with an aqueous sodium bicarbonate solution
4. dry with materialwith water, dried
5. customevaporated
6. customThe residual oil was recrystallized from cyclohexane