HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 1-(3-Methoxybenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | m-Anisoyl chloride | HCID 74374 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 3-[2-(2-Cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole | HCID 21313365 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(3-Methoxybenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole | HCID 21313341 | — |
Reaction Steps
1-(3-Methoxybenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole is prepared by reaction of 3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole with sodium hydride in DMF and reaction of the resulting sodium salt with 3-methoxybenzoyl chloride following the procedure described above in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04021431 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-13954d4adec34849aef739b6b1a7a098 |
| Source note | uspto-grants-1977_05 |