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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2397491Generated: October 26, 2026

Sodium hydride → 1-(2,4-Difluorobenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole

https://huagongshe.com/reaction/2397491

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium hydrideHCID 24758—
Reactant2,4-Difluorobenzoyl chlorideHCID 588081—
ReactantSodiumHCID 5360545—
Reactant3-[2-(2-Cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindoleHCID 21313365—
SolventDimethylformamideHCID 6228—
Product1-(2,4-Difluorobenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindoleHCID 21313419—

Reaction Steps

1-(2,4-Difluorobenzoyl)-3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole is prepared by reaction of 3-[2-(2-cyclohexylmethylpiperidino)ethyl]-5-methoxy-2-methylindole with sodium hydride in DMF and reaction of the resulting sodium salt with 2,4-difluorobenzoyl chloride following the procedure described above in Example 1.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04021431
Source datasetuspto-grants-1977_05
ORD IDord-4b665b57eddf4106a876ef2fef90bdb5
Source noteuspto-grants-1977_05