m-Chloroperbenzoic acid → HCID 21435654, compound

Participants

Reaction Steps

6.56 g. of 5-methyl-2-methylthio-4-phenylthiazole pre-dissolved in 100 ml. of methylene chloride is cooled in an ice bath. The stirred solution is treated with 6.01 g. of m-chloroperoxybenzoic acid, added in portions over five minutes. After 30 minutes, the reaction is complete and the precipitated m-chlorobenzoic acid is filtered and the filtrate washed successively with a 10% solution of sodium sulfite, saturated aqueous sodium bicarbonate solution and water. After drying, concentration in vacuo and chromatography yields a white solid, m.p. 96°-97° C.

Provenance & Evidence