Methoxyisopropylamine → HCID 20543892, compound

Participants

Reaction Steps

163 g of titanium tetrachloride in 800 ml of toluene were added dropwise to a solution of 229 g (1.64 mole) of 2-ethyl-6-methylcyclohexanon and 435 g (4.9 mole) of 1-methyl-2-methoxyethylamine in 1000 ml toluene and 110 ml of ether over a period of two hours with stirring and at a temperature of between 0°-10° C. After distilling off the ether the reaction mixture was refluxed for 61/2 hours. After cooling the precipitate was filtered off and the filtrate concentrated in a rotary evaporator at 50° C. Distillation of the residue under reduced pressure gave 174 g 2-ethyl-6-methyl-N-(1-methyl-2-methoxyethyl)-cyclohexylidene-amine, m.p. 109°-113° C./15 Torr.

Provenance & Evidence