Triethylamine → HCID 54498521, compound

Participants

Reaction Steps

A mixture of 20 g. of chloromethylated polystyrene resin having 1.16 mmole of chlorine per gram, and 8 g. of Nα-t-butoxycarbonyl-O-benzyl-L-threonine in 500 ml. of ethanol is treated with 2.6 g. of triethylamine and refluxed for three days in excess ethanol. The resin is separated by filtration, washed with ethanol, water, methanol, dichloromethane and ether, successively, and then dried overnight at 40° C. giving the Nα-butoxycarbonyl-O-benzyl-L-threonine resin.

Provenance & Evidence