Aluminium lithium hydride → HCID 21435857, compound

HRID 2397521Notes

Reaction equation

HRID 2397521 reaction equation
[CH2:1]([C:3]1([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=2)[CH2:9][N:8]([CH3:10])[C:7](=O)[CH:6]([CH3:12])[CH2:5][CH2:4]1)[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>CCOCC>[CH2:1]([C:3]1([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([O:19][CH3:20])[CH:14]=2)[CH2:4][CH2:5][CH:6]([CH3:12])[CH2:7][N:8]([CH3:10])[CH2:9]1)[CH3:2]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 21435858HCID 21435858, compound

Product 1

HCID 21435857HCID 21435857, compoundYield 89.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Epimer `B` of 6-ethyl-6-(m-methoxyphenyl)-1,3-dimethylhexahydro-2H-azepin-2-one [Example 1 (ii) (a); 2.8 g.] in dry ether (20 ml.) was reduced with lithium aluminium hydride (1 g.) according to the procedure of Example 2. After work up, the colourless oil was distilled affording the title compound (2.39 g.), b.p. 106°-110° C. 0.1mm.

Workup

  1. distillationAfter work up, the colourless oil was distilled

Sources & evidence

ORD record
ord-c7fca03ad2bf4444ac36de69b01e0845
Source dataset
uspto-grants-1977_05
Patent number
US04022764

Reaction notes

Loading…