HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 12282573, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo- | HCID 81242 | — |
| Reactant | (4-amino-2-methyl-5-phenyl-1H-pyrrol-3-yl)-phenylmethanone | HCID 3042143 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | HCID 12282573 | HCID 12282573 | — |
Reaction Steps
4-Amino-3-benzoyl-2-methyl-5-phenylpyrrole (22.4 g.) is dissolved in 1400 ml. of chloroform and 160 ml. of 1N sodium hydroxide are added to the mixture. By keeping the temperature at 0°-5° C., 17.6 g. of phthalimidoacetyl chloride in 120 ml. of chloroform are added with stirring. After one hour the reaction mixture is cooled and the solid precipitated is recovered on filter and then crystallized from ethanol. Yield 27.8 g.; M.p. 288°-90° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04022766 |
| Source dataset | uspto-grants-1977_05 |
| ORD ID | ord-376fa9ea4a83434cac792b16f325c34e |
| Source note | uspto-grants-1977_05 |